Search results for "Malignant peripheral nerve sheath tumor"

showing 3 items of 3 documents

Malignant peripheral nerve sheath tumor of the maxila

2005

Summary We present a case of a malignant peripheral nerve sheath tumor [MPNST] of the maxilla corresponding to a 12 year old male who had a painful, ulcerated rapid growing tumor. Histology revealed the presence of a tumor consisting of fusiform cells with abundant mitosis, with negative cytokeratins, actin, desmin, myoglobin and factor VIII. In contrast, the protein S-100 was positive. MPNST was not associated with signs of Neurofibromatosis Type 1. The patient was surgically intervened and received radiotherapy, then died within 10 months posterior to surgical intervention after suffering recurrence.

Pathologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentHistologyMalignant peripheral nerve sheath tumormedicine.diseasePathology and Forensic MedicineRadiation therapyNeurosarcomaOncologyOtorhinolaryngologyMaxillaMaxillaMedicineDesminMalignant peripheral nerve sheath tumorNeurofibromatosisOral SurgerybusinessOral Oncology Extra
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Malignant Peripheral Nerve Sheath Tumor With Osseous Heterologous Differentiation in Uncommon Locations (Heart and Retropharynx)

2016

We report two cases of malignant peripheral nerve sheath tumor (MPNST) in an uncommon location (heart and retropharynx) both with divergent osseous heterologous differentiation. We present the pathological and immunohistochemical studies that confirmed the neurogenic origin. The histopathology of the tumor arising in the retropharynx showed a transition from a neurofibroma to MPNST, making this a new report of an MPNST arising from a plexiform neurofibroma without neurofibromatosis. Primary cardiac MPNST with osseous differentiation has never been reported before. In conclusion, the histology of MPNSTs is very heterogeneous, showing no specific diagnostic immunoprofile or genetic alteration…

AdultMalemedicine.medical_specialtyPathologySoft Tissue NeoplasmHeterologousSoft Tissue NeoplasmsMalignant peripheral nerve sheath tumor030204 cardiovascular system & hematologyBiologyPathology and Forensic MedicineHeart NeoplasmsYoung Adult03 medical and health sciences0302 clinical medicinePlexiform neurofibromaBiomarkers TumormedicineHumansNeurofibromamalignant peripheral nerve sheath tumorNeurofibromatosisNeurofibroma PlexiformOssification HeterotopicCell Differentiationmedicine.diseaseImmunohistochemistrydivergent heterologous differentiation030220 oncology & carcinogenesisPharynxImmunohistochemistryFemaleSurgeryHistopathologyheart and retropharynxAnatomyNeurilemmoma
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Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

2010

Background Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosar…

medicine.medical_specialtyPathologybusiness.industryMalignant peripheral nerve sheath tumorHematologyLiposarcomamedicine.diseaseOncologyPediatrics Perinatology and Child HealthmedicineCarcinomaRadiologyGerm cell tumorsTeratomaSarcomaChondrosarcomaRhabdomyosarcomabusinessPediatric Blood & Cancer
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